., 2000). This sparing of CB1 receptors next peripheral nerve harm could reveal a possible therapeutic benefit of cannabinoids over opioids inside the treatment of neuropathic agony. This hypothesis is even further supported by a recent study (Mao et al

Tricyclic antidepressants and specified anticonvulsants will be the mainstay of clinical therapy for neuropathic discomfort (McQuay et al

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Neuropathic agony is defined as ‘agony initiated or a result of a Key lesion or dysfunction while in the nervous method' (Merskey & Bogduk, 1994) and is particularly an area of mainly unmet therapeutic need to have.

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An extra breakthrough inside the elucidation of cannabinoid pharmacology came in 1988 with the invention of the cannabinoid receptor in rat Mind (CB1, Devane et al

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